Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC7773638 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhang Pengfei P Shen Hanqin H Liu Xianhui X Wang Shuangyun S Liu Yanling Y Xu Zheng Z Song Changxu C
Frontiers in veterinary science 20201217
Porcine circovirus 3 (PCV3) infections cause clinical diseases similar to those seen in porcine circovirus 2 (PCV2) infections. It is unclear whether PCV3 infections can also cause immunosuppression like that seen with PCV2. Here, we report that Cap inhibits DNA-induced IFN-β mRNA transcription and IFN promoter activation. Cap was also found to inhibit cyclic GMP-AMP (cGAMP) synthase (cGAS) binding to interferon-stimulating DNA (ISD). Immunoprecipitation and mass spectrometry were used to identi ...[more]