Ontology highlight
ABSTRACT:
SUBMITTER: Kang G
PROVIDER: S-EPMC7774503 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kang Gyunghoon G Taguchi Alexander T AT Stubbe JoAnne J Drennan Catherine L CL
Science (New York, N.Y.) 20200326 6489
Ribonucleotide reductases (RNRs) are a diverse family of enzymes that are alone capable of generating 2'-deoxynucleotides de novo and are thus critical in DNA biosynthesis and repair. The nucleotide reduction reaction in all RNRs requires the generation of a transient active site thiyl radical, and in class I RNRs, this process involves a long-range radical transfer between two subunits, α and β. Because of the transient subunit association, an atomic resolution structure of an active α2β2 RNR c ...[more]