Dataset Information

Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.

ABSTRACT: Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes.

SUBMITTER: Gregorova M

PROVIDER: S-EPMC7775105 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.

Gregorova Michaela M Morse Daniel D Brignoli Tarcisio T Steventon Joseph J Hamilton Fergus F Albur Mahableshwar M Arnold David D Thomas Matthew M Halliday Alice A Baum Holly H Rice Christopher C Avison Matthew B MB Davidson Andrew D AD Santopaolo Marianna M Oliver Elizabeth E Goenka Anu A Finn Adam A Wooldridge Linda L Amulic Borko B Boyton Rosemary J RJ Altmann Daniel M DM Butler David K DK McMurray Claire C Stockton Joanna J Nicholls Sam S Cooper Charles C Loman Nicholas N Cox Michael J MJ Rivino Laura L Massey Ruth C RC

eLife 20201217

Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by <i>Pseudomonas aeruginosa</i> that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and <i>P. aeruginosa</i> specific, and bystander activated, which may have contributed to this pat ...[more]

PMID: 33331820

Dataset Information

Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.

Publications

Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.

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