Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC7775748 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Li Wen W Qiu Jianhua J Li Xiang-Ling XL Aday Sezin S Zhang Jingdong J Conley Grace G Xu Jun J Joseph John J Lan Haoyue H Langer Robert R Mannix Rebekah R Karp Jeffrey M JM Joshi Nitin N
Science advances 20210101 1
Small interfering RNA (siRNA)-based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB). One approach to overcoming this challenge involves treatment administration while BBB is transiently breached after injury. However, it offers a limited window for therapeutic intervention and is applicable to only a subset of injuries with substantially breached BBB. We report a nanoparticle platform for BBB ...[more]