Association of naturally occurring antibodies to ?-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Liu YH
PROVIDER: S-EPMC7775771 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer's disease.
Liu Yu-Hui YH Wang Jun J Li Qiao-Xin QX Fowler Christopher J CJ Zeng Fan F Deng Juan J Xu Zhi-Qiang ZQ Zhou Hua-Dong HD Doecke James D JD Villemagne Victor L VL Lim Yen Ying YY Masters Colin L CL Wang Yan-Jiang YJ
Science advances 20210101 1
The pathological relevance of naturally occurring antibodies to β-amyloid (NAbs-Aβ) in Alzheimer's disease (AD) remains unclear. We aimed to investigate their levels and associations with Aβ burden and cognitive decline in AD in a cross-sectional cohort from China and a longitudinal cohort from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. NAbs-Aβ levels in plasma and cerebrospinal fluid (CSF) were tested according to their epitopes. Levels of NAbs targeting the amino terminus o ...[more]
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