Ontology highlight
ABSTRACT:
SUBMITTER: Schneider N
PROVIDER: S-EPMC7775772 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Science advances 20210101 1
Light-inducible gene switches represent a key strategy for the precise manipulation of cellular events in fundamental and applied research. However, the performance of widely used gene switches is limited due to low tissue penetrance and possible phototoxicity of the light stimulus. To overcome these limitations, we engineer optogenetic synthetic transcription factors to undergo liquid-liquid phase separation in close spatial proximity to promoters. Phase separation of constitutive and optogenet ...[more]