Ontology highlight
ABSTRACT:
SUBMITTER: Louwe MC
PROVIDER: S-EPMC7775960 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Louwe Mieke C MC Olsen Maria B MB Kaasbøll Ole J OJ Yang Kuan K Fosshaug Linn E LE Alfsnes Katrine K Øgaard Jonas D S JDS Rashidi Azita A Skulberg Vidar M VM Yang Mingyi M de Miranda Fonseca Davi D Sharma Animesh A Aronsen Jan Magnus JM Schrumpf Elisabeth E Ahmed Muhammad Shakil MS Dahl Christen Peder CP Nyman Tuula A TA Ueland Thor T Melum Espen E Halvorsen Bente E BE Bjørås Magnar M Attramadal Håvard H Sjaastad Ivar I Aukrust Pål P Yndestad Arne A
JACC. Basic to translational science 20201209 12
An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function following MI, in mice deficient for the NLRP3 inflammasome, can be recapitulated in wild-type mice receiving bone marrow from <i>Nlrp3</i> <sup><i>-/-</i></sup> mice. This suggests that NLRP3 activation in hematopoietic cells infiltrating in the myocardium increases mortality an ...[more]