Ontology highlight
ABSTRACT:
SUBMITTER: Clayman PD
PROVIDER: S-EPMC7778473 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20200903 37
Flavin-dependent "ene"-reductases can generate stabilized alkyl radicals when irradiated with visible light; however, they are not known to form unstabilized radicals. Here, we report an enantioselective radical cyclization using alkyl iodides as precursors to unstabilized nucleophilic radicals. Evidence suggests this species is accessed by photoexcitation of a charge-transfer complex that forms between flavin and substrate within the protein active site. Stereoselective delivery of a hydrogen a ...[more]