Ontology highlight
ABSTRACT:
SUBMITTER: Beyerstedt S
PROVIDER: S-EPMC7778857 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Beyerstedt Stephany S Casaro Expedito Barbosa EB Rangel Érika Bevilaqua ÉB
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20210103 5
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell surfaces through which SARS-CoV-2 enters the host cells and is highly expressed in the heart, kidneys, and lungs and shed into the plasma. ACE2 is a key regulator of the renin-angiotensin-aldosterone system (RAAS). SARS-CoV-2 causes ACE/ACE2 balance disruption and RAAS activation, which leads ultimately to COVID-19 progression, espec ...[more]