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DIGGER: exploring the functional role of alternative splicing in protein interactions.

ABSTRACT: Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing.

SUBMITTER: Louadi Z

PROVIDER: S-EPMC7778957 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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DIGGER: exploring the functional role of alternative splicing in protein interactions.

Louadi Zakaria Z Yuan Kevin K Gress Alexander A Tsoy Olga O Kalinina Olga V OV Baumbach Jan J Kacprowski Tim T List Markus M

Nucleic acids research 20210101 D1

Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friend ...[more]

PMID: 32976589

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