Effect of LPS and LTA stimulation on the expression of TLR-pathway genes in PBMCs of Akkaraman lambs in vivo.
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ABSTRACT:
SUBMITTER: Aksel EG
PROVIDER: S-EPMC7779097 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Effect of LPS and LTA stimulation on the expression of TLR-pathway genes in PBMCs of Akkaraman lambs in vivo.
Aksel Esma Gamze EG Akyüz Bilal B
Tropical animal health and production 20210103 1
This is the first study investigating the changes in some gene expressions related to the TLR pathway in vivo in sheep. Lipopolysaccharide (LPS) and lipoteichoic acid (LTA) molecules were administrated separately and in combination to the Akkaraman lambs via intranasal route. For this purpose, 28 lambs were distributed into four groups (LPS, LTA, LPS + LTA, and control, n = 7). Blood samples were collected to isolate the peripheral blood mononuclear cells (PBMCs) at 24 h and on day 7. Expression ...[more]
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