Dataset Information

Survival and Prognostic Factors for Breast Cancer Patients with Regional Oligo-Recurrence.

ABSTRACT:

Purpose

This study aimed to evaluate survival outcomes and identify prognostic factors for regional oligo-recurrence in breast cancer patients who received salvage local treatment.

Methods

In the breast cancer registry of our institution, 18,790 patients received curative surgery for stage I-III breast cancer between January 1995 and June 2016. Of those patients, only 87 (0.5%)underwent salvage local treatment for isolated nodal recurrence on the axillary lymph nodes (ALNs) (n = 58), supraclavicular lymph nodes (SCNs) (n = 17), or internal mammary lymph nodes (IMNs) (n = 12).

Results

The median follow-up duration after regional oligo-recurrence was 49 months (range: 6-194 months). For patients with recurrence of ALN, SCN, or IMN, the 5-year progression-free survival (PFS) and overall survival (OS) rates were 40.0%, 32.1%, and 25.0%, respectively (p = 0.3) and 62.7%, 70.0%, and 58.3%, respectively(p = 0.97). In the multivariable analysis for PFS, age at recurrence ? 65 years, disease-free interval < 24 months, non-luminal A subtype, and in-field failure (marginally significant) were found to be risk factors (RFs). However, the location of the tumor was not a significant factor for PFS (p = 0.71). When we stratified patients by the number of RFs, the 5-year PFS rates were 67.5% for patients with ? 1 RF and 7.3% for those with > 1 RF (p < 0.01). For patients with ? 1 RF, the 5-year PFS rates were 73.5% in the ALN group and 51.1% in the SCN/IMN group (p = 0.09). For patients with > 1 RF, the 5-year PFS rates were 7.3% in the ALN group and 7.1% in the SCN/IMN group (p = 1.00).

Conclusion

In breast cancer patients with regional oligo-recurrence, clinical outcomes after salvage treatment were favorable in patients with ? 1 RF, while patients with > 1 RF had poor prognoses irrespective of the location of recurrence.

SUBMITTER: Baek JY

PROVIDER: S-EPMC7779728 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Survival and Prognostic Factors for Breast Cancer Patients with Regional Oligo-Recurrence.

Baek Jong Yun JY Choi Doo Ho DH Park Won W Kim Haeyoung H Cho Won Kyung WK Yoo Gyu Sang GS

Journal of breast cancer 20201201 6

<h4>Purpose</h4>This study aimed to evaluate survival outcomes and identify prognostic factors for regional oligo-recurrence in breast cancer patients who received salvage local treatment.<h4>Methods</h4>In the breast cancer registry of our institution, 18,790 patients received curative surgery for stage I-III breast cancer between January 1995 and June 2016. Of those patients, only 87 (0.5%)underwent salvage local treatment for isolated nodal recurrence on the axillary lymph nodes (ALNs) (n = 5 ...[more]

PMID: 33408888

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Dataset Information

Survival and Prognostic Factors for Breast Cancer Patients with Regional Oligo-Recurrence.

Purpose

Methods

Results

Conclusion

Publications

Survival and Prognostic Factors for Breast Cancer Patients with Regional Oligo-Recurrence.

Similar Datasets

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