Ontology highlight
ABSTRACT:
SUBMITTER: Thonsri U
PROVIDER: S-EPMC7780024 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Thonsri Unchalee U Wongkham Sopit S Wongkham Chaisiri C Hino Shinjiro S Nakao Mitsuyoshi M Roytrakul Sittiruk S Koga Tomoaki T Seubwai Wunchana W
Cancer science 20201129 1
Diabetes is a major risk factor in the development and progression of several cancers including cholangiocarcinoma (CCA). However, the molecular mechanism by which hyperglycemia potentiates progression of CCA is not clearly understood. Here, we showed that a high glucose condition significantly increased reactive oxygen species (ROS) production and promoted aggressive phenotypes of CCA cells, including proliferation and migration activities. Mannosidase alpha class 2a member 2 (MAN2A2), was upre ...[more]