Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.

ABSTRACT: Repeated maternal separation is the most widely used pre-clinical approach to investigate the relationship between early-life chronic stress and its neuropsychiatric and physical consequences. In this systematic review, we identified 46 studies that conducted repeated maternal separation or single-episode maternal separation and reported measurements of interleukin-1b, interleukin-6, interleukin-10, tumour necrosis factor-alpha, or microglia activation and density. We report that in the short-term and in the context of later-life stress, repeated maternal separation has pro-inflammatory immune consequences in diverse tissues. Repeated maternal separation animals exhibit greater microglial activation and elevated pro-inflammatory cytokine signalling in key brain regions implicated in human

SUBMITTER: Dutcher EG 

PROVIDER: S-EPMC7780197 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature