Kinetics of changes in gene and microRNA expression related with muscle inflammation and protein degradation following LPS-challenge in weaned piglets.
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ABSTRACT:
SUBMITTER: Kang P
PROVIDER: S-EPMC7780359 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Kinetics of changes in gene and microRNA expression related with muscle inflammation and protein degradation following LPS-challenge in weaned piglets.
Kang Ping P Huang Xingfa X Wan Zhicheng Z Liang Tianzeng T Wang Yang Y Li Xiangen X Zhang Jing J Zhu Huiling H Liu Yulan Y
Innate immunity 20201124 1
To test the dynamic changes of the expression of genes and microRNA in the gastrocnemius muscle after LPS challenge, 36 piglets were assigned to a control group (slaughtered 0 h after saline injection) and LPS groups (slaughtered at 1 h, 2 h, 4 h, 8 h, and 12 h after LPS treatment, respectively). After LPS treatment, the mRNA expression of IL-1β, IL-6, and TNF-α reached maximal levels at 1 h, 2 h, and 1 h, respectively (<i>P</i> < 0.05), and mRNA expression of TLR4, NODs, muscle-specific ring fi ...[more]
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