Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC7780690 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Zhang Feifei F Wang Hui H Yu Jiang J Yao Xueqing X Yang Shibin S Li Weidong W Xu Lijun L Zhao Liang L
Molecular cancer 20210104 1
De novo and acquired resistance, which are mainly mediated by genetic alterations, are barriers to effective routine chemotherapy. However, the mechanisms underlying gastric cancer (GC) resistance to chemotherapy are still unclear. We showed that the long noncoding RNA CRNDE was related to the chemosensitivity of GC in clinical samples and a PDX model. CRNDE was decreased and inhibited autophagy flux in chemoresistant GC cells. CRNDE directly bound to splicing protein SRSF6 to reduce its protein ...[more]