Genetic Markers of ADHD-Related Variations in Intracranial Volume.

ABSTRACT:

Objective

Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, and putamen are smaller in people with ADHD compared with healthy individuals. The authors investigated the overlap between common genetic variation associated with ADHD risk and these brain volume measures to identify underlying biological processes contributing to the disorder.

Methods

The authors combined genome-wide association results from the largest available studies of ADHD (N=55,374) and brain volumes (N=11,221-24,704), using a set of complementary methods to investigate overlap at the level of global common variant

SUBMITTER: Klein M 

PROVIDER: S-EPMC7780894 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature