Ontology highlight
ABSTRACT:
SUBMITTER: Baisa G
PROVIDER: S-EPMC7781324 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Baisa Gary G Rancour David D Mansfield Keith K Burns Monika M Martin Lori L Cunha Daise D Fischer Jessica J Muecksch Frauke F Hatziioannou Theodora T Bieniasz Paul D PD Schomburg Fritz F Luke Kimberly K
bioRxiv : the preprint server for biology 20201221
Vaccines that generate robust and long-lived protective immunity against SARS-CoV-2 infection are urgently required. We assessed the potential of vaccine candidates based on the SARS-CoV-2 spike in cynomolgus macaques (<i>M. fascicularis</i>) by examining their ability to generate spike binding antibodies with neutralizing activity. Antigens were derived from two distinct regions of the spike S1 subunit, either the N-terminal domain (NTD) or an extended C-terminal domain containing the receptor- ...[more]