Substrate specificity of bacterial endoribonuclease toxins.
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ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC7781912 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Substrate specificity of bacterial endoribonuclease toxins.
BMB reports 20201201 12
Bacterial endoribonuclease toxins belong to a protein family that inhibits bacterial growth by degrading mRNA or rRNA sequences. The toxin genes are organized in pairs with its cognate antitoxins in the chromosome and thus the activities of the toxins are antagonized by antitoxin proteins or RNAs during active translation. In response to a variety of cellular stresses, the endoribonuclease toxins appear to be released from antitoxin molecules via proteolytic cleavage of antitoxin proteins or pre ...[more]
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