Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity.
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ABSTRACT:
SUBMITTER: Ryan KA
PROVIDER: S-EPMC7782478 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity.
Ryan Kathryn A KA Bewley Kevin R KR Fotheringham Susan A SA Slack Gillian S GS Brown Phillip P Hall Yper Y Wand Nadina I NI Marriott Anthony C AC Cavell Breeze E BE Tree Julia A JA Allen Lauren L Aram Marilyn J MJ Bean Thomas J TJ Brunt Emily E Buttigieg Karen R KR Carter Daniel P DP Cobb Rebecca R Coombes Naomi S NS Findlay-Wilson Steve J SJ Godwin Kerry J KJ Gooch Karen E KE Gouriet Jade J Halkerston Rachel R Harris Debbie J DJ Hender Thomas H TH Humphries Holly E HE Hunter Laura L Ho Catherine M K CMK Kennard Chelsea L CL Leung Stephanie S Longet Stephanie S Ngabo Didier D Osman Karen L KL Paterson Jemma J Penn Elizabeth J EJ Pullan Steven T ST Rayner Emma E Skinner Oliver O Steeds Kimberley K Taylor Irene I Tipton Tom T Thomas Stephen S Turner Carrie C Watson Robert J RJ Wiblin Nathan R NR Charlton Sue S Hallis Bassam B Hiscox Julian A JA Funnell Simon S Dennis Mike J MJ Whittaker Catherine J CJ Catton Michael G MG Druce Julian J Salguero Francisco J FJ Carroll Miles W MW
Nature communications 20210104 1
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-CoV-2 in the ferret model. After a high (5 × 10<sup>6</sup> pfu) and medium (5 × 10<sup>4</sup> pfu) dose of virus is delivered, intranasally, viral RNA shedding in the upper respiratory tract (URT) is observed in 6/6 animals, however, only 1/6 ferrets show similar signs after low dose (5 × 10<sup>2</sup> pfu) chall ...[more]
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