Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus.

ABSTRACT: The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited the identification of several known cell types. In this study, we used single-cell RNA-seq in morphologically identified parvalbumin interneurons (PV-INs), and studied their transcriptomic states in the morphological, physiological, and developmental domains. Overall, we find high transcriptomic similarity among PV-INs, with few genes showing divergent expression between morphologically different types. Furthermore, PV-INs show a uniform synaptic cell adhesion molecule (CAM) pro

SUBMITTER: Que L 

PROVIDER: S-EPMC7782706 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature