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Recent Advances in the Development of TGF-? Signaling Inhibitors for Anticancer Therapy.

ABSTRACT: TGF-? is a multifunctional cytokine that plays an important role in both physiologic and pathologic processes, including cancer. Importantly, TGF-? has a dual role in tumorigenesis, acting as a tumor suppressor or a tumor promoter, depending on the stage of tumor development. The aberrantly upregulated production of TGF-? has been strongly implicated in tumor progression, angiogenesis, and metastasis, as well as immune evasion. Therefore, hyperactivated TGF-? signaling is considered a potential therapeutic target for cancer therapy. Numerous inhibitors of overactivated TGF-? signaling have been developed, and some of them are currently in clinical trials. This review focuses on the TGF-? signaling that contributes to tumor progression and immune evasion in the tumor microenvironment and presents recent achievements on TGF-? signaling inhibition as a single or combined therapeutic approach in cancer therapy.

SUBMITTER: Lee HJ

PROVIDER: S-EPMC7783242 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Recent Advances in the Development of TGF-β Signaling Inhibitors for Anticancer Therapy.

Lee Ho-Jae HJ

Journal of cancer prevention 20201201 4

TGF-β is a multifunctional cytokine that plays an important role in both physiologic and pathologic processes, including cancer. Importantly, TGF-β has a dual role in tumorigenesis, acting as a tumor suppressor or a tumor promoter, depending on the stage of tumor development. The aberrantly upregulated production of TGF-β has been strongly implicated in tumor progression, angiogenesis, and metastasis, as well as immune evasion. Therefore, hyperactivated TGF-β signaling is considered a potential ...[more]

PMID: 33409254

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