Dataset Information

Canadian Pediatric Neuro-Oncology Standards of Practice.

ABSTRACT: Primary CNS tumors are the leading cause of cancer-related death in pediatrics. It is essential to understand treatment trends to interpret national survival data. In Canada, children with CNS tumors are treated at one of 16 tertiary care centers. We surveyed pediatric neuro-oncologists to create a national standard of practice to be used in the absence of a clinical trial for seven of the most prevalent brain tumors in children. This allowed description of practice across the country, along with a consensus. This had a multitude of benefits, including understanding practice patterns, allowing for a basis to compare in future research and informing Health Canada of the current management of patients. This also allows all children in Canada to receive equivalent care, regardless of location.

SUBMITTER: Bennett J

PROVIDER: S-EPMC7783450 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Canadian Pediatric Neuro-Oncology Standards of Practice.

Bennett Julie J Erker Craig C Lafay-Cousin Lucie L Ramaswamy Vijay V Hukin Juliette J Vanan Magimairajan I MI Cheng Sylvia S Coltin Hallie H Fonseca Adriana A Johnston Donna D Lo Andrea A Zelcer Shayna S Alvi Saima S Bowes Lynette L Brossard Josée J Charlebois Janie J Eisenstat David D Felton Kathleen K Fleming Adam A Jabado Nada N Larouche Valérie V Legault Geneviève G Mpofu Chris C Perreault Sébastien S Silva Mariana M Sinha Roona R Strother Doug D Tsang Derek S DS Wilson Beverly B Crooks Bruce B Bartels Ute U

Frontiers in oncology 20201222

Primary CNS tumors are the leading cause of cancer-related death in pediatrics. It is essential to understand treatment trends to interpret national survival data. In Canada, children with CNS tumors are treated at one of 16 tertiary care centers. We surveyed pediatric neuro-oncologists to create a national standard of practice to be used in the absence of a clinical trial for seven of the most prevalent brain tumors in children. This allowed description of practice across the country, along wit ...[more]

PMID: 33415075

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Project description:ObjectivesMRI remains the preferred imaging investigation for glioblastoma. Appropriate and timely neuroimaging in the follow-up period is considered to be important in making management decisions. There is a paucity of evidence-based information in current UK, European and international guidelines regarding the optimal timing and type of neuroimaging following initial neurosurgical treatment. This study assessed the current imaging practices amongst UK neuro-oncology centres, thus providing baseline data and informing future practice.MethodsThe lead neuro-oncologist, neuroradiologist and neurosurgeon from every UK neuro-oncology centre were invited to complete an online survey. Participants were asked about current and ideal imaging practices following initial treatment.ResultsNinety-two participants from all 31 neuro-oncology centres completed the survey (100% response rate). Most centres routinely performed an early post-operative MRI (87%, 27/31), whereas only a third performed a pre-radiotherapy MRI (32%, 10/31). The number and timing of scans routinely performed during adjuvant TMZ treatment varied widely between centres. At the end of the adjuvant period, most centres performed an MRI (71%, 22/31), followed by monitoring scans at 3 monthly intervals (81%, 25/31). Additional short-interval imaging was carried out in cases of possible pseudoprogression in most centres (71%, 22/31). Routine use of advanced imaging was infrequent; however, the addition of advanced sequences was the most popular suggestion for ideal imaging practice, followed by changes in the timing of EPMRI.ConclusionVariations in neuroimaging practices exist after initial glioblastoma treatment within the UK. Multicentre, longitudinal, prospective trials are needed to define the optimal imaging schedule for assessment.Key points• Variations in imaging practices exist in the frequency, timing and type of interval neuroimaging after initial treatment of glioblastoma within the UK. • Large, multicentre, longitudinal, prospective trials are needed to define the optimal imaging schedule for assessment.

Dataset Information

Canadian Pediatric Neuro-Oncology Standards of Practice.

Publications

Canadian Pediatric Neuro-Oncology Standards of Practice.

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