Dataset Information

Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events Through a Modified Delphi Process.

ABSTRACT:

Importance

There is little evidence to support patient-centered outcomes in patients with cardiovascular disease.

Objective

To derive patient-defined adverse cardiovascular and noncardiovascular events (PACE) through a consensus-based process.

Design, setting, and participants

This pan-Canadian, consensus-based, qualitative study used an iterative Delphi method to achieve consensus within a 35-member panel consisting of patients with cardiovascular diseases and their caregivers and clinicians. The process included 4 rounds of online questionnaires, followed by an in-person final consensus meeting. Data analysis was performed in September 2019.

Main outcomes and measures

Defining PACE as a 5-item composite outcome.

Results

Thirty-five potential panelists consented to participate, including 11 clinicians (8 men [73%]) and 24 patients and caregivers (13 men [54%]). Twenty-nine (83%), 28 (80%), 26 (74%), and 23 (66%) of the panelists participated in each of respective the online rounds. A shortlist of 11 patient-defined items was further refined at the in-person meeting, which 20 of the panelists attended. The PACE definition that was decided through the consensus process was a composite of severe stroke necessitating hospitalization for 14 days or longer or inpatient rehabilitation, ventilator dependence, new onset or worsening heart failure, nursing home admission, or new onset dialysis.

Conclusions and relevance

This study defined PACE as a versatile, patient-centered outcome through a consensus process with input from patients, caregivers, and clinicians. Given the paucity of patient-centered outcomes in cardiovascular research, PACE may be considered as a potential outcome after methodological evaluation of its reliability.

SUBMITTER: Sun LY

PROVIDER: S-EPMC7783543 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events Through a Modified Delphi Process.

Sun Louise Y LY Rodger Jillian J Duffett Lisa L Tulloch Heather H Crean Andrew M AM Chong Aun-Yeong AY Rubens Fraser D FD MacPhee Erika E Mesana Thierry G TG Lee Douglas S DS van Diepen Sean S Beanlands Rob S RS Ruel Marc M Julien Ann-Marie AM Bilodeau Jean J

JAMA network open 20210104 1

<h4>Importance</h4>There is little evidence to support patient-centered outcomes in patients with cardiovascular disease.<h4>Objective</h4>To derive patient-defined adverse cardiovascular and noncardiovascular events (PACE) through a consensus-based process.<h4>Design, setting, and participants</h4>This pan-Canadian, consensus-based, qualitative study used an iterative Delphi method to achieve consensus within a 35-member panel consisting of patients with cardiovascular diseases and their caregi ...[more]

PMID: 33394003

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Dataset Information

Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events Through a Modified Delphi Process.

Importance

Objective

Design, setting, and participants

Main outcomes and measures

Results

Conclusions and relevance

Publications

Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events Through a Modified Delphi Process.

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