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Larvicidal activity of novel anthraquinone analogues and their molecular docking studies


ABSTRACT: To investigate the larvicidal activities of novel anthraquinones (1a-1k) against Culex quinquefasciatus mosquito larvae. Novel anthraquinones (1a-1k) derivatives were synthesis via condensation method. The compounds were confirmed through FT-IR spectroscopy, 1H & 13C NMR spectrum, and mass spectral studies. The larvicidal activity of compound 1c was highly active LD50 20.92 µg/mL against Culex quinquefasciatus compared standard permethrin with LD50 25.49 µg/mL. Molecular docking studies were carried out for compound 1c against Odorant-binding protein of Culex quinquefasciatus. The compound 1c (?9.8 Kcal/mol) was a potent larvicide with more binding energy than control permethrin (?9.7 Kcal/mol). Therefore, compound (1c) may be more significant inhibitors of mosquito larvicidal.

SUBMITTER: Selvaraj K 

PROVIDER: S-EPMC7783635 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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