Browse
Submit Data
Databases
API
Help

Dataset Information

17 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection.

ABSTRACT: The outbreak of coronavirus disease 2019 has seriously threatened human health. Rapidly and sensitively detecting SARS-CoV-2 viruses can help control the spread of viruses. However, it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity. Therefore, it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity. Herein we report, for the first time, Nb₂C and Ta₂C MXenes exhibit a remarkable SERS enhancement, which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement. Their SERS sensitivity is optimized to 3.0 × 10⁶ and 1.4 × 10⁶ under the optimal resonance excitation wavelength of 532 nm. Additionally, remarkable SERS sensitivity endows Ta₂C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein. Moreover, its detection limit is as low as 5 × 10^-9 M, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus. This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology.

SUBMITTER: Peng Y

PROVIDER: S-EPMC7783703 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Silver Nanorods Wrapped with Ultrathin Al2O3 Layers Exhibiting Excellent SERS Sensitivity and Outstanding SERS Stability.

Project description:Silver nanostructures have been considered as promising substrates for surface-enhanced Raman scattering (SERS) with extremely high sensitivity. The applications, however, are hindered by the facts that their morphology can be easily destroyed due to the low melting points (~100 °C) and their surfaces are readily oxidized/sulfured in air, thus losing the SERS activity. It was found that wrapping Ag nanorods with an ultrathin (~1.5 nm) but dense and amorphous Al2O3 layer by low-temperature atomic layer deposition (ALD) could make the nanorods robust in morphology up to 400 °C, and passivate completely their surfaces to stabilize the SERS activity in air, without decreasing much the SERS sensitivity. This simple strategy holds great potentials to generate highly robust and stable SERS substrates for real applications.

| S-EPMC4533008 | biostudies-literature

Assessing Plasmonic Nanoprobes in Electromagnetic Field Enhancement for SERS Detection of Biomarkers.

Project description:The exploration of the plasmonic field enhancement of nanoprobes consisting of gold and magnetic core@gold shell nanoparticles has found increasing application for the development of surface-enhanced Raman spectroscopy (SERS)-based biosensors. The understanding of factors controlling the electromagnetic field enhancement, as a result of the plasmonic field enhancement of the nanoprobes in SERS biosensing applications, is critical for the design and preparation of the optimal nanoprobes. This report describes findings from theoretical calculations of the electromagnetic field intensity of dimer models of gold and magnetic core@gold shell nanoparticles in immunoassay SERS detection of biomarkers. The electromagnetic field intensities for a series of dimeric nanoprobes with antibody-antigen-antibody binding defined interparticle distances were examined in terms of nanoparticle sizes, core-shell sizes, and interparticle spacing. The results reveal that the electromagnetic field enhancement not only depended on the nanoparticle size and the relative core size and shell thicknesses of the magnetic core@shell nanoparticles but also strongly on the interparticle spacing. Some of the dependencies are also compared with experimental data from SERS detection of selected cancer biomarkers, showing good agreement. The findings have implications for the design and optimization of functional nanoprobes for SERS-based biosensors.

| S-EPMC8706705 | biostudies-literature

Composition-adjustable Ag-Au substitutional alloy microcages enabling tunable plasmon resonance for ultrasensitive SERS.

Project description:Engineering the surface plasmon resonance (SPR) properties is a critical issue for improving device performance in the fields of plasmonics, nanophotonics, optoelectronics, and electrochemistry. Here, we demonstrated a programmable manipulation of the surface plasmon resonance (SPR) effect using composition-adjustable Ag-Au substitutional alloy microcages (SAMCs) through a facile NaBH4-cooperative galvanic replacement reaction. The SPR frequency of the Ag-Au SAMCs can be continuously and exquisitely manipulated without resonance damping or broadening via accurate adjustment of the elemental composition distribution at the perfect homogeneity on the atomic-level. Significantly, both the tunable SPR frequency and excellent chemical stability synergistically endow the hollow Ag-Au SAMCs with excellent SERS sensitivity and reproducibility, which lays a foundation for the realization of trace detection of thiram at an ultralow concentration of 1 × 10-12 M. This strategy is a promising candidate for efficient promotion of the SERS activity for metal-based substrates.

| S-EPMC5944819 | biostudies-other

Active site-dominated electromagnetic enhancement of surface-enhanced Raman spectroscopy (SERS) on a Cu triangle plate.

Project description:Revealing the sensitivity and selectivity of the Raman enhancement mechanism is extremely significant for disease diagnosis, environmental surveillance, and food safety supervision. In this study, chemical erosion copper triangle plates (CTPs) were employed as SERS substrate to detect the rhodamine B (Rh B) probe molecule at different etching times. A simple and cost-effective method affords unique insights into the surface enrichment of analytes, which could facilitate the high-performance SERS analysis of numerous analytes. The relationship between the Raman intensity and the concentration of Rh B follows the Freundlich model, which means that the wet-etching surface can create SERS-active site attachment Rh B molecules on the CTPs. The morphology of CTPs was modified by H2O2/HCl etchants; however, the composition of CTPs remained stable without oxidation. This proposes that the largest contribution to the enhancement was the hot-spots that can produce surface plasma resonance on the CTPs. The number of hot-spots can be intelligently adjusted by the artificial control of the surface morphology of metal materials, providing an unambiguous improvement in the SERS sensitivity and capability.

| S-EPMC9057851 | biostudies-literature

Tuning Electromagnetic Parameters Induced by Synergistic Dual-Polarization Enhancement Mechanisms with Amorphous Cobalt Phosphide with Phosphorus Vacancies for Excellent Electromagnetic Wave Dissipation Performance.

Project description:The understanding of amorphous and heterojunction materials has been widely used in the field of electromagnetic wave absorption due to their unique physical and chemical properties. However, the effectiveness of individual strategies currently used is still limited. Well-designed compositions and amorphous structures simplify the effect of different polarization mechanisms on the absorption of electromagnetic waves. In this work, through the carbonization and controlled phosphating of one-dimensional Co Metal-Organic Framework (Co-MOF) nanorods, the synthesis of complex components and amorphous CoPx with phosphorus vacancies is successfully accomplished, thus adjusting the optimization of electromagnetic parameters. Phosphorus-vacancy-induced defective polarization loss and enhanced-electronegativity-differences-induced dipole polarization loss synergistically as a dual-polarization strategy significantly improved the electromagnetic parameters and impedance matching. In conclusion, the electromagnetic parameters of the Co@CoPx@C composites are indeed significantly regulated, with reflection losses of -55 dB and a bandwidth of up to 5.5 GHz. These innovative research ideas provide instructive thinking for the development of amorphous absorbers with vacancies.

| S-EPMC10708327 | biostudies-literature

Molecular engineering of organic semiconductors enables noble metal-comparable SERS enhancement and sensitivity.

Project description:Nanostructured molecular semiconductor films are promising Surface-Enhanced Raman Spectroscopy (SERS) platforms for both fundamental and technological research. Here, we report that a nanostructured film of the small molecule DFP-4T, consisting of a fully π-conjugated diperfluorophenyl-substituted quaterthiophene structure, demonstrates a very large Raman enhancement factor (>105) and a low limit of detection (10-9 M) for the methylene blue probe molecule. This data is comparable to those reported for the best inorganic semiconductor- and even intrinsic plasmonic metal-based SERS platforms. Photoluminescence spectroscopy and computational analysis suggest that both charge-transfer energy and effective molecular interactions, leading to a small but non-zero oscillator strength in the charge-transfer state between the organic semiconductor film and the analyte molecule, are required to achieve large SERS enhancement factors and high molecular sensitivities in these systems. Our results provide not only a considerable experimental advancement in organic SERS figure-of-merits but also a guidance for the molecular design of more sensitive SERS systems.

| S-EPMC6890673 | biostudies-literature

Phase controlled SERS enhancement.

Project description:Surface-enhanced Raman spectroscopy (SERS) has attracted increasing interest for chemical and biochemical sensing. Several studies have shown that SERS intensities are significantly increased when an optical interference substrate composed of a dielectric spacer and a reflector is used as a supporting substrate. However, the origin of this additional enhancement has not been systematically studied. In this paper, high sensitivity SERS substrates composed of self-assembled core-satellite nanostructures and silica-coated silicon interference layers have been developed. Their SERS enhancement is shown to be a function of the thickness of silica spacer on a more reflective silicon substrate. Finite difference time domain modeling is presented to show that the SERS enhancement is due to a spacer contribution via a sign change of the reflection coefficients at the interfaces. The magnitude of the local-field enhancement is defined by the interference of light reflected from the silica-air and silica-silicon interfaces, which constructively added at the hot spots providing a possibility to maximize intensity in the nanogaps between the self-assembled nanoparticles by changing the thickness of silica layer. The core-satellite assemblies on a 135 nm silica-coated silicon substrate exhibit a SERS activity of approximately 13 times higher than the glass substrate.

| S-EPMC6346009 | biostudies-literature

Mxenes-Au NP Hybrid Plasmonic 2D Microplates in Microfluidics for SERS Detection.

Project description:Combined with microfluidics, surface-enhanced Raman spectroscopy (SERS) exhibits huge application prospective in sensitive online detection. In current studies, the design and optimization of plasmonic enhanced structures in microfluidics for SERS detection could be an interesting challenge. In this work, hybrid plasmonic 2D microplates composed of Mxenes (Ti3C2Tx) microplates and in-situ synthesized Au nanoparticles (Au NPs) are fabricated in a microchannel for enhanced structures in SERS microfluidics. Benefiting from the 2D Mxenes microplates with complex distributions, the enhanced areas generated by Au NPs are quite enlarged in a microchannel, which exhibits high sensitivity in SERS detection at 10-10 M for Nile blue (NB) molecules in microfluidics. The mechanism of electromagnetic enhancement (EM) and chemical enhancement (CM) is analyzed. The experimental data indicate the ultrasonic times of Mxenes and the concentration of Au3+ play important roles in the sensitivity of SERS detection, which is confirmed by the simulated electric field distributions. Furthermore, a typical pesticide (thiram) at 100 ppm in water is detected on these SERS microfluidics with hybrid plasmonic enhanced structures, which demonstrates that our work not only strengthens the knowledge of plasmonics but also enlarges the application of SERS.

| S-EPMC9312844 | biostudies-literature

Ultrathin, Lightweight, and Flexible CNT Buckypaper Enhanced Using MXenes for Electromagnetic Interference Shielding.

Project description:Lightweight, flexibility, and low thickness are urgent requirements for next-generation high-performance electromagnetic interference (EMI) shielding materials for catering to the demand for smart and wearable electronic devices. Although several efforts have focused on constructing porous and flexible conductive films or aerogels, few studies have achieved a balance in terms of density, thickness, flexibility, and EMI shielding effectiveness (SE). Herein, an ultrathin, lightweight, and flexible carbon nanotube (CNT) buckypaper enhanced using MXenes (Ti3C2Tx) for high-performance EMI shielding is synthesized through a facile electrophoretic deposition process. The obtained Ti3C2Tx@CNT hybrid buckypaper exhibits an outstanding EMI SE of 60.5 dB in the X-band at 100 μm. The hybrid buckypaper with an MXene content of 49.4 wt% exhibits an EMI SE of 50.4 dB in the X-band with a thickness of only 15 μm, which is 105% higher than that of pristine CNT buckypaper. Furthermore, an average specific SE value of 5.7 × 104 dB cm2 g-1 is exhibited in the 5-μm hybrid buckypaper. Thus, this assembly process proves promising for the construction of ultrathin, flexible, and high-performance EMI shielding films for application in electronic devices and wireless communications.

| S-EPMC8187523 | biostudies-literature

Vibrational enhancement of quadrature squeezing and phase sensitivity in resonance fluorescence.

Project description:Vibrational environments are commonly considered to be detrimental to the optical emission properties of solid-state and molecular systems, limiting their performance within quantum information protocols. Given that such environments arise naturally it is important to ask whether they can instead be turned to our advantage. Here we show that vibrational interactions can be harnessed within resonance fluorescence to generate optical states with a higher degree of quadrature squeezing than in isolated atomic systems. Considering the example of a driven quantum dot coupled to phonons, we demonstrate that it is feasible to surpass the maximum level of squeezing theoretically obtainable in an isolated atomic system and indeed come close to saturating the fundamental upper bound on squeezing from a two-level emitter. We analyse the performance of these vibrationally-enhanced squeezed states in a phase estimation protocol, finding that for the same photon flux, they can outperform the single mode squeezed vacuum state.

| S-EPMC6620290 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data