Ontology highlight
ABSTRACT:
SUBMITTER: Palmos AB
PROVIDER: S-EPMC7784985 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Palmos Alish B AB Duarte Rodrigo R R RRR Smeeth Demelza M DM Hedges Erin C EC Nixon Douglas F DF Thuret Sandrine S Powell Timothy R TR
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20200913 13
Short telomere length is a risk factor for age-related disease, but it is also associated with reduced hippocampal volumes, age-related cognitive decline and psychiatric disorder risk. The current study explored whether telomere shortening might have an influence on cognitive function and psychiatric disorder pathophysiology, via its hypothesised effects on adult hippocampal neurogenesis. We modelled telomere shortening in human hippocampal progenitor cells in vitro using a serial passaging prot ...[more]