Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial.

ABSTRACT:

Objective

The short-term effect (60 days) of Lactobacillus brevis CD2 lozenges vs placebo on variables related to caries and gingivitis in type 1 diabetic children was evaluated.

Material and methods

Eight diabetics (4-14 years old) were assigned to two groups (n = 34 subjects each), probiotic lozenges and placebo. Stimulated saliva for microbiological analysis and plaque pH were assessed at baseline (t₀), 30 days (t₁), 60 days (t₂) and in the follow-up period (90 days from baseline, t₃). Gingival status was assessed at t₀, t₂ and t₃. Two-way ANOVA assessed differences between groups.

Results

In the probiotic group, Streptococcus mutans bacterial density mean scores dropped from 3.11 ± 1.13 at baseline to 1.82 ± 0.72 (t₂) and to 2.06 ± 0.56 (t₃), while in the placebo group, the scores were 3.09 ± 0.8 (t₀), 2.82 ± 0.47 (t₂) and 3.11 ± 0.43 (t₃) (p < 0.01). Lowest and maximum pH fall increased in the probiotic group, from 5.37 ± 0.41 at baseline to 5.49 ± 0.24 at t₃ (p < 0.01) and from 1.20 ± 0.46 to 0.98 ± 0.29 (p = 0.02). Bleeding score decreased significantly in both groups, showing a statistically significant lower bleeding score at t₂ in the probiotic group (25.6%, 95% CI 21.5-32.7 vs 29.5%, 95% CI 25.2-34.9, p = 0.02).

Conclusions

Lactobacillus brevis CD2 has shown to improve caries-related risk factors and gingival health in diabetic children.

Clinical relevance

Lactobacillus brevis CD2 might contribute to improved oral health in type 1 diabetic children.

SUBMITTER: Lai S 

PROVIDER: S-EPMC7785539 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature