Ontology highlight
ABSTRACT:
SUBMITTER: Le SC
PROVIDER: S-EPMC7786149 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Cell reports 20201201 13
Calcium (Ca<sup>2+</sup>) is the primary stimulus for transmembrane protein 16 (TMEM16) Ca<sup>2+</sup>-activated chloride channels and phospholipid scramblases, which regulate important physiological processes ranging from smooth muscle contraction to blood coagulation and tumor progression. Binding of intracellular Ca<sup>2+</sup> to two highly conserved orthosteric binding sites in transmembrane helices (TMs) 6-8 efficiently opens the permeation pathway formed by TMs 3-7. Recent structures of ...[more]