Ontology highlight
ABSTRACT:
SUBMITTER: Criswell SR
PROVIDER: S-EPMC7786890 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Criswell Susan R SR Nielsen Susan Searles SS Warden Mark N MN Perlmutter Joel S JS Moerlein Stephen M SM Sheppard Lianne L Lenox-Krug Jason J Checkoway Harvey H Racette Brad A BA
Journal of occupational and environmental medicine 20201001 10
<h4>Objective</h4>To understand the neurotoxic effects of manganese (Mn) exposure on monoaminergic function, utilizing [C]dihydrotetrabenazine (DTBZ) positron emission tomography (PET) to measure vesicular monoamine transporter 2 (VMAT2).<h4>Methods</h4>Basal ganglia and thalamic DTBZ binding potentials (BPND) were calculated on 56 PETs from 41 Mn-exposed workers. Associations between cumulative Mn exposure, regional BPND, and parkinsonism were examined by mixed linear regression.<h4>Results</h4 ...[more]