Actual long-term survival after resection of stage III soft tissue sarcoma.

ABSTRACT:

Background

Actuarial survival based on the Kaplan-Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. Therefore, we aimed to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III STS.

Methods

We retrospectively reviewed 116 patients who underwent surgical resection for stage III STS with curative intent between March 2000 and December 2013. Long-term survivors (n?=?61), defined as those who survived beyond 5?years, were compared with short-term survivors (n?=?36), who died of STS within 5?years.

Results

Multivariate logistic regression analyses showed that a tumor size ?10?cm and 48% had a histological grade of 3. Leiomyosarcoma (3 of 10) was negatively associated with actual long-term survival.

Conclusions

Actual 5-year survival after resection of stage III STS was associated with tumor size, histological grade, and ASA score. However, majority of the actual 5-year survivors exhibit factors of poor prognosis, suggesting that aggressive treatment should be offered for a chance of long-term survival in these patients.

SUBMITTER: Lee DW 

PROVIDER: S-EPMC7786893 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature