Ontology highlight
ABSTRACT:
SUBMITTER: Nonaka M
PROVIDER: S-EPMC7787448 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Nonaka Motohiro M Mabashi-Asazuma Hideaki H Jarvis Donald L DL Yamasaki Kazuhiko K Akama Tomoya O TO Nagaoka Masato M Sasai Toshio T Kimura-Takagi Itsuko I Suwa Yoichi Y Yaegashi Takashi T Huang Chun-Teng CT Nishizawa-Harada Chizuko C Fukuda Michiko N MN
PloS one 20210106 1
We previously reported that IF7 peptide, which binds to the annexin A1 (ANXA1) N-terminus, functions as a tumor vasculature-targeted drug delivery vehicle after intravenous injection. To enhance IF7 stability in vivo, we undertook mirror-image peptide phage display using a synthetic D-peptide representing the ANXA1 N-terminus as target. We then identified peptide sequences, synthesized them as D-amino acids, and designated the resulting peptide dTIT7, which we showed bound to the ANXA1 N-terminu ...[more]