Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders.
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ABSTRACT:
SUBMITTER: Wong H
PROVIDER: S-EPMC7787664 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders.
Wong Helen H Levenga Josien J LaPlante Lauren L Keller Bailey B Cooper-Sansone Andrew A Borski Curtis C Milstead Ryan R Ehringer Marissa M Hoeffer Charles C
eLife 20201216
AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single <i>Akt</i> isoform, conditional brain-specific <i>Akt1</i>, and double <i>Akt1/3</i> mutant mice in behaviors relevant to neuropsychiatric disorders. Because sex is a determinant of these disorders but poorly understood, sex was an experimental variable in our design. Our studies revealed AKT isofor ...[more]
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