Dataset Information

The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer.

ABSTRACT:

Background

A female prognostic advantage in younger individuals has been demonstrated in various cancers. Several large-scale analyses based on different racial backgrounds have reported inconsistent results in colorectal cancer. The aim of the present study was to evaluate the prognostic value of sex and age in patients with colorectal cancer of different ethnic groups.

Methods

We identified 71,812 eligible patients from the Surveillance, Epidemiology and End Results database. According to age at diagnosis, the patients were categorized into premenopausal age (?45?yrs), menopausal age (46-54?yrs), and postmenopausal age (?55?yrs) subgroups for further analysis.

Results

Multivariate analysis identified the female survival advantage to be significant in the premenopausal age subgroup (P = 0.002, HR (95% CI): 0.73 (0.60-0.89)), diminished in the menopausal age subgroup (P = 0.09), and absent in the postmenopausal age subgroup (P = 0.96). Furthermore, the female survival advantage at premenopausal age was significant only in white patients (P = 0.001, HR (95% CI): 0.68 (0.54-0.87)) and not in either American Indian/Alaska Native or Asian or Pacific Islander patients. There was a trend of better survival of females in black patients (P = 0.07).

Conclusions

Sex was a major prognostic factor in colorectal cancer patients, especially premenopausal women, and the difference was also associated with race.

SUBMITTER: Sheng H

PROVIDER: S-EPMC7787739 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer.

Sheng Hui H Wei Xiaoli X Chen Qunxi Q Huang Kewei K Han Runkun R Liu Yijun Y Liu Wen W Mao Minjie M

BioMed research international 20201230

<h4>Background</h4>A female prognostic advantage in younger individuals has been demonstrated in various cancers. Several large-scale analyses based on different racial backgrounds have reported inconsistent results in colorectal cancer. The aim of the present study was to evaluate the prognostic value of sex and age in patients with colorectal cancer of different ethnic groups.<h4>Methods</h4>We identified 71,812 eligible patients from the Surveillance, Epidemiology and End Results database. Ac ...[more]

PMID: 33457414

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Project description:Preclinical data indicate that oestrogen appears to play a beneficial role in the pathophysiology of and recovery from critical illness. In few previous epidemiologic studies, however, have researchers analysed premenopausal women as a separate group when addressing potential gender differences in critical care outcome. Our aim was to see if women of premenopausal age have a better outcome following critical care and to investigate the association between gender and use of intensive care unit (ICU) resources.On the basis of our analysis of 127,254 consecutive Simplified Acute Physiology Score III-scored Swedish Intensive Care Registry ICU admissions from 2008 through 2012, we determined the risk-adjusted 30-day mortality, accumulated nurse workload score and ICU length of stay. To investigate associations with sex, we used logistic regression and multivariate analyses on the entire cohort as well as on two subgroups stratified by median age for menopause (up to and including 45 years and older than 45 years) and six selected diagnostic subgroups (sepsis, multiple trauma, chronic obstructive pulmonary disease, acute respiratory distress syndrome, pneumonia and cardiac arrest).There was no sex difference in risk-adjusted mortality for the cohort as a whole, and there was no sex difference in risk-adjusted mortality in the group 45 years of age and younger. For the group of patients older than 45 years of age, we found a reduced risk-adjusted mortality in men admitted for cardiac arrest. For the cohort as a whole, and for those admitted with multiple trauma, male sex was associated with a higher nurse workload score and a longer ICU stay.Using information derived from a large multiple ICU register database, we found that premenopausal female sex was not associated with a survival advantage following intensive care in Sweden. When the data were adjusted for age and severity of illness, we found that men used more ICU resources per admission than women did.

Dataset Information

The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer.

Background

Methods

Results

Conclusions

Publications

The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer.

Similar Datasets

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