Ontology highlight
ABSTRACT: Introduction and hypothesis
In randomized clinical trials onabotulinumtoxinA was demonstrated to be an effective and well-tolerated treatment for overactive bladder (OAB) with urinary incontinence (UI). However, data reporting onabotulinumtoxinA use in everyday clinical practice are limited. Here, we present the results from a large, first-of-its-kind real-world study in patients with OAB.Methods
This was a prospective, observational, multinational study (GRACE; ClinicalTrials.gov , NCT02161159) performed in four European countries. Patients (N?=?504) aged ? 18 years with OAB inadequately managed with ? 1 anticholinergic received onabotulinumtoxinA per their physician's normal clinical practice.Results
Physicians primarily used rigid cystoscopes for onabotulinumtoxinA injection; anesthesia/analgesia was utilized during most treatment procedures. Significant reductions in UI episodes/day from baseline to weeks 1 and 12 were observed as well as in micturition, urgency, and nocturia episodes/day. These improvements in urinary symptoms corresponded to higher scores on the treatment benefit scale at week 12. The use of other OAB medications dropped from baseline to weeks 1 and 12 and was sustained to week 52, which paralleled a reduction in the number of incontinence products used during that time frame. Adverse reactions were reported in 2.6% of patients throughout the study.Conclusions
In this real-world study, significant improvements in urinary symptoms were seen following onabotulinumtoxinA treatment as early as week 1 and sustained to at least week 12. This was accompanied by a reduced reliance upon incontinence products and reduction in concomitant OAB medication use. OnabotulinumtoxinA was well tolerated with no new safety signals.
SUBMITTER: Hamid R
PROVIDER: S-EPMC7788019 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Hamid Rizwan R Lorenzo-Gomez Maria-Fernanda MF Schulte-Baukloh Heinrich H Boroujerdi Amin A Patel Anand A Farrelly Elisabeth E
International urogynecology journal 20200727 1
<h4>Introduction and hypothesis</h4>In randomized clinical trials onabotulinumtoxinA was demonstrated to be an effective and well-tolerated treatment for overactive bladder (OAB) with urinary incontinence (UI). However, data reporting onabotulinumtoxinA use in everyday clinical practice are limited. Here, we present the results from a large, first-of-its-kind real-world study in patients with OAB.<h4>Methods</h4>This was a prospective, observational, multinational study (GRACE; ClinicalTrials.go ...[more]