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Women with temporomandibular disorders: Untargeted proton nuclear magnetic resonance spectroscopy-based metabolomics of saliva and psychological instruments dataset.

ABSTRACT: This article introduces the first dataset of 1H- nuclear magnetic resonance - based metabolomic spectroscopy of saliva samples from women with temporomandibular disorders (TMD) of muscular origin. Our data generated a metabolomic profile for TMD of muscular origin. The samples were separated in two groups: Experimental Group (EG) represented by women with TMD who were submitted to a conservative treatment compared with a Control group (CG) of women without TMD. These data also include information about time of onset the pain, measures of pain obtained before and after the treatment by the visual analogic scale. Information about some psychological instruments as pain catrastophizing scale, hospital anxiety and depression, and oral health impact profile-14 were also obtained in the CG and in the EG before submitted to the conservative treatment (EG-pre) and at the end of the treatment (EG-post). Those instruments help differentiate the groups, due to the psychosocial impact that TMD has on their lives perpetuating the physiological imbalance of the stomatognathic system. Raw data are available at: https://data.mendeley.com/datasets/wys5xd2vfg/1. It's published on mendeley, the DOI is DOI:10.17632/wys5xd2vfg.1. The data presented in this article are related to the research article entitled "1H-NMR-Based salivary metabolomics from female with temporomandibular disorders - a pilot study" (Lalue Sanches et al. 2020, https://doi.org/10.1016/j.cca.2020.08.006).

SUBMITTER: Sanches ML

PROVIDER: S-EPMC7788092 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundPyridoxine-dependent epilepsy (PDE-ALDH7A1) is an inborn error of lysine catabolism that presents with refractory epilepsy in newborns. Biallelic ALDH7A1 variants lead to deficiency of α-aminoadipic semialdehyde dehydrogenase/antiquitin, resulting in accumulation of piperideine-6-carboxylate (P6C), and secondary deficiency of the important cofactor pyridoxal-5'-phosphate (PLP, active vitamin B6) through its complexation with P6C. Vitamin B6 supplementation resolves epilepsy in patients, but intellectual disability may still develop. Early diagnosis and treatment, preferably based on newborn screening, could optimize long-term clinical outcome. However, no suitable PDE-ALDH7A1 newborn screening biomarkers are currently available.MethodsWe combined the innovative analytical methods untargeted metabolomics and infrared ion spectroscopy to discover and identify biomarkers in plasma that would allow for PDE-ALDH7A1 diagnosis in newborn screening.ResultsWe identified 2S,6S-/2S,6R-oxopropylpiperidine-2-carboxylic acid (2-OPP) as a PDE-ALDH7A1 biomarker, and confirmed 6-oxopiperidine-2-carboxylic acid (6-oxoPIP) as a biomarker. The suitability of 2-OPP as a potential PDE-ALDH7A1 newborn screening biomarker in dried bloodspots was shown. Additionally, we found that 2-OPP accumulates in brain tissue of patients and Aldh7a1-knockout mice, and induced epilepsy-like behavior in a zebrafish model system.ConclusionThis study has opened the way to newborn screening for PDE-ALDH7A1. We speculate that 2-OPP may contribute to ongoing neurotoxicity, also in treated PDE-ALDH7A1 patients. As 2-OPP formation appears to increase upon ketosis, we emphasize the importance of avoiding catabolism in PDE-ALDH7A1 patients.FundingSociety for Inborn Errors of Metabolism for Netherlands and Belgium (ESN), United for Metabolic Diseases (UMD), Stofwisselkracht, Radboud University, Canadian Institutes of Health Research, Dutch Research Council (NWO), and the European Research Council (ERC).

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Women with temporomandibular disorders: Untargeted proton nuclear magnetic resonance spectroscopy-based metabolomics of saliva and psychological instruments dataset.

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