Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7788460 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Li Yapu Y Wang Ding D Wang Hongtao H Huang Xin X Wen Yuqi Y Wang BingRui B Xu Changlu C Gao Jie J Liu Jinhua J Tong Jingyuan J Wang Mengge M Su Pei P Ren Sirui S Ma Feng F Li Hong-Dong HD Bresnick Emery H EH Zhou Jiaxi J Shi Lihong L
EMBO reports 20201215 1
Alternative splicing (AS) leads to transcriptome diversity in eukaryotic cells and is one of the key regulators driving cellular differentiation. Although AS is of crucial importance for normal hematopoiesis and hematopoietic malignancies, its role in early hematopoietic development is still largely unknown. Here, by using high-throughput transcriptomic analyses, we show that pervasive and dynamic AS takes place during hematopoietic development of human pluripotent stem cells (hPSCs). We identif ...[more]