Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia.

ABSTRACT:

Importance

Behavioral disturbances are core features of frontotemporal dementia (FTD); however, symptom progression across the course of disease is not well characterized in genetic FTD.

Objective

To investigate behavioral symptom frequency and severity and their evolution and progression in different forms of genetic FTD.

Design, setting, and participants

This longitudinal cohort study, the international Genetic FTD Initiative (GENFI), was conducted from January 30, 2012, to May 31, 2019, at 23 multicenter specialist tertiary FTD research clinics in the United Kingdom, the Netherlands, Belgium, France, Spain, Portugal, Italy, Germany, Sweden, Finland, and Canada. Participants included a consecutive sample of 232 symptomatic FTD gene variation carriers comprising 115

SUBMITTER: Benussi A 

PROVIDER: S-EPMC7788468 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature