Dataset Information

Aluminum-Substituted Keggin Germanotungstate [HAl(H₂O)GeW₁₁O₃₉]^4-: Synthesis, Characterization, and Antibacterial Activity.

ABSTRACT: We report on the new monosubstituted aluminum Keggin-type germanotungstate (C₄H₁₂N)₄[HAlGeW₁₁O₃₉(H₂O)]·11H₂O ([Al(H₂O)GeW₁₁]^4-), which has been synthesized at room temperature via rearrangement of the dilacunary [?-GeW₁₀O₃₆]^8- polyoxometalate precursor. [Al(H₂O)GeW₁₁]^4- has been characterized thoroughly both in the solid state by single-crystal and powder X-ray diffraction, IR spectroscopy, thermogravimetric analysis, and elemental analysis as well as in solution by cyclic voltammetry (CV) ¹⁸³W, ²⁷Al NMR and UV-vis spectroscopy. A study on the antibacterial properties of [Al(H₂O)GeW₁₁]^4- and the known aluminum(III)-centered Keggin polyoxotungstates (Al-POTs) ?-Na₅[AlW₁₂O₄₀] (?-[AlW₁₂O₄₀]^5-) and Na₆[Al(AlOH₂)W₁₁O₃₉] ([Al(AlOH₂)W₁₁O₃₉]^6-) revealed enhanced activity for all three Al-POTs against the Gram-negative bacterium Moraxella catarrhalis (minimum inhibitory concentration (MIC) up to 4 ?g mL^-1) and the Gram-positive Enterococcus faecalis (MIC up to 128 ?g mL^-1) compared to the inactive Al(NO₃)₃ salt (MIC > 256 ?g mL^-1). CV indicates the redox activity of the Al-POTs as a dominating factor for the observed antibacterial activity with increased tendency to reduction, resulting in increased antibacterial activity of the POT.

SUBMITTER: Tanuhadi E

PROVIDER: S-EPMC7788568 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Aluminum-Substituted Keggin Germanotungstate [HAl(H2O)GeW11O39]4-: Synthesis, Characterization, and Antibacterial Activity.

Tanuhadi Elias E Gumerova Nadiia I NI Prado-Roller Alexander A Galanski Mathea Sophia MS Čipčić-Paljetak Hana H Verbanac Donatella D Rompel Annette A

Inorganic chemistry 20201217 1

We report on the new monosubstituted aluminum Keggin-type germanotungstate (C4H12N)4[HAlGeW11O39(H2O)]·11H2O ([Al(H2O)GeW11]4-), which has been synthesized at room temperature via rearrangement of the dilacunary [γ-GeW10O36]8- polyoxometalate precursor. [Al(H2O)GeW11</su ...[more]

PMID: 33332970

Similar Datasets

Project description:BackgroundThe ?-amyloid radiotracer [11C] PiB is extensively used for the Positron Emission Tomography (PET) diagnosis of Alzheimer's Disease and related dementias. For clinical use, [11C] PiB is produced using the 11C-methylation method ([11C] Methyl iodide or [11C] methyl triflate as 11C-methylation agents), which represents the most employed 11C-labelling strategy for the synthesis of 11C-radiopharmaceuticals. Recently, the use of direct [11C]CO2 fixation for the syntheses of 11C-tracers has gained interest in the radiochemical community due to its importance in terms of radiochemical versatility and for permitting the direct employment of the cyclotron-produced precursor [11C]CO2. This paper presents an optimised alternative one-pot methodology of [11C]CO2 fixation-reduction for the rapid synthesis of [11C] PiB using an automated commercial platform and its quality control.Results[11C] PiB was obtained from a (25.9?±?13.2)% (Average?±?Variation Coefficient, n?=?3) (end of synthesis, decay corrected) radiochemical yield from trapped [11C]CO2 after 1?min of labelling time using PhSiH3 / TBAF as the fixation-reduction system in Diglyme at 150?°C. The radiochemical purity was higher than 95% in all cases, and the molar activity was (61.4?±?1.6) GBq/?mol. The radiochemical yield and activity (EOS) of formulated [11C] PiB from cyclotron-produced [11C]CO2 was (14.8?±?12.1)%, decay corrected) and 9.88?GBq (± 6.0%), respectively. These are higher values compared to that of the 11C-methylation method with [11C]CH3OTf (~?8.3%).ConclusionsThe viability of the system PhSiH3 / TBAF to efficiently promote the radiosynthesis of [11C] PiB via direct [11C]CO2 fixation-reduction has been demonstrated. [11C] PiB was obtained through a fully automated radiosynthesis with a satisfactory yield, purity and molar activity. According to the results, the one-pot methodology employed could reliably yield sufficiently high tracer amounts for preclinical and clinical use.

Dataset Information

Aluminum-Substituted Keggin Germanotungstate [HAl(H₂O)GeW₁₁O₃₉]^4-: Synthesis, Characterization, and Antibacterial Activity.

Publications

Aluminum-Substituted Keggin Germanotungstate [HAl(H<sub>2</sub>O)GeW<sub>11</sub>O<sub>39</sub>]<sup>4-</sup>: Synthesis, Characterization, and Antibacterial Activity.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure