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Association between decreased thyroid stimulating hormone and hyperuricemia in type 2 diabetic patients with early-stage diabetic kidney disease.


ABSTRACT:

Background

Serum uric acid (SUA) is associated with the development of diabetic kidney disease (DKD). Thyroid hormones can regulate metabolism and insulin resistance. The relationship between SUA and thyroid function in patients with DKD is still uncertain. In current study, we aimed to investigate the association between thyroid stimulating hormone (TSH) and SUA in type 2 diabetic patients with early-stage DKD.

Methods

Two hundred fifty-four type 2 diabetic patients with early-stage DKD were enrolled in current study and were further classified as high SUA group (SUA level?>?420??mol/L in males or?>?360??mol/L in females, n?=?101) and normal SUA group (SUA level???420??mol/L in males or???360??mol/L in females, n?=?153). Eighty-five control subjects were recruited as control group. The clinical characteristics were obtained via face-to-face surveys and medical records.

Results

Compared with normal SUA group and control group, high SUA group exhibited the increased SUA level, and the decreased TSH level (P?ConclusionsTSH is negatively correlated with SUA, and decreased TSH is an independent risk factor for hyperuricemia in type 2 diabetic patients with early-stage DKD. These results indicate that thyroid hormones, TSH in particular, might participate in regulating uric acid metabolism in patients with early-stage DKD.

SUBMITTER: Feng X 

PROVIDER: S-EPMC7788793 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Association between decreased thyroid stimulating hormone and hyperuricemia in type 2 diabetic patients with early-stage diabetic kidney disease.

Feng Xiaomeng X   Huang Jing J   Peng Yan Y   Xu Yuan Y  

BMC endocrine disorders 20210106 1


<h4>Background</h4>Serum uric acid (SUA) is associated with the development of diabetic kidney disease (DKD). Thyroid hormones can regulate metabolism and insulin resistance. The relationship between SUA and thyroid function in patients with DKD is still uncertain. In current study, we aimed to investigate the association between thyroid stimulating hormone (TSH) and SUA in type 2 diabetic patients with early-stage DKD.<h4>Methods</h4>Two hundred fifty-four type 2 diabetic patients with early-st  ...[more]

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