Ontology highlight
ABSTRACT:
SUBMITTER: Bury JJ
PROVIDER: S-EPMC7788898 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Bury Joanna J JJ Chambers Annabelle A Heath Paul R PR Ince Paul G PG Shaw Pamela J PJ Matthews Fiona E FE Brayne Carol C Simpson Julie E JE Wharton Stephen B SB
Acta neuropathologica communications 20210106 1
Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, we investigated the transcriptomic changes in cortical neurones, and associated astrocytes and endothelial cells of the neurovascular unit, in the ageing brain. Neurone, astrocyte, and endothelial cell-enriched mRNA, obtained by immuno-laser ca ...[more]