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Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates.


ABSTRACT:

Background

Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), procalcitonin (PCT) and CRP with subsequent sepsis severity and mortality in preterm infants suspected of late onset neonatal sepsis.

Methods

The study was conducted at the Erasmus University Medical Center-Sophia Children's Hospital Rotterdam. Patient data from January 2018 until October 2019 were reviewed for all preterm neonates born with a gestational age below 32 weeks with signs and symptoms suggestive of systemic infection, in whom blood was taken for blood culture and for inflammatory biomarkers determinations. Plasma IL-6 and PCT were assessed next to CRP at the moment of suspicion. We assessed the association with 7-day mortality and sepsis severity (neonatal sequential organ failure assessment (nSOFA) score, need for inotropic support, invasive ventilation and thrombocytopenia).

Results

A total of 480 suspected late onset neonatal sepsis episodes in 208 preterm neonates (gestational age?ConclusionsOur findings show that serum IL-6 and PCT levels at moment of suspected late onset neonatal sepsis offer valuable information about sepsis severity and mortality risk in infants born below 32 weeks of gestation. The discriminative value was superior to that of CRP. Determining these biomarkers in suspected sepsis may help identify patients with imminent severe sepsis, who may require more intensive monitoring and therapy.

SUBMITTER: Kurul S 

PROVIDER: S-EPMC7788923 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates.

Kurul Şerife Ş   Simons Sinno H P SHP   Ramakers Christian R B CRB   De Rijke Yolanda B YB   Kornelisse René F RF   Reiss Irwin K M IKM   Taal H Rob HR  

Critical care (London, England) 20210106 1


<h4>Background</h4>Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), procalcitonin (PCT) and CRP with subsequent sepsis severity and mortality in preterm infants suspected of late onset neonatal sepsis.<h4>Methods</h4>The study was conducted at  ...[more]

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