The presence of erosive joints is a strong predictor of radiological progression in hand osteoarthritis: results of a 2-year prospective follow-up of the Liege Hand Osteoarthritis Cohort (LIHOC).

ABSTRACT:

Background

This study measured the magnitude and determinants of clinical and radiological progression in patients with hand osteoarthritis (HOA) over a 2-year prospective follow-up to gain a greater understanding of the disease time course.

Methods

Two hundred three consecutive outpatients diagnosed with HOA were followed for 2?years (183 women, median age 69?years). Pain and function were evaluated using the Australian/Canadian Osteoarthritis Hand Index (AUSCAN), and clinical examination recorded the number of painful/swollen joints and nodes. X-rays were scored using Kellgren-Lawrence (KL) and Verbruggen-Veys scales. Clinical progression was defined as deterioration in AUSCAN ? the minimal clinically important difference. Radiographic progression was defined as (a) one new erosive/remodeled joint, (b) progression of ? one anatomical stage in one joint, or (c) change in KL total score above the smallest detectable difference. Logistic regression was performed to determine whether patient characteristics influenced clinical and radiological progression.

Results

After 2?years, all radiographic scores deteriorated significantly in the study population (p ConclusionsEvidence of radiological progression over 2?years was observed in patients with HOA in the LIHOC population even without clinical worsening of disease. For individual patients, baseline pain level is predictive for clinical progression and the presence of erosive or swollen joints are significant predictors of radiological progression.

SUBMITTER: Neuprez A 

PROVIDER: S-EPMC7788934 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature