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Global proteome profiling of human livers upon ischemia/reperfusion treatment.


ABSTRACT: Hepatic ischemia/reperfusion (I/R) injury represents a major risk factor for liver transplantation and is related to graft dysfunction and acute/chronic rejection. However, a significant part of these processes remain poorly characterized. To reveal differences in the proteome during liver I/R injury, we collected human liver biopsy samples during hepatectomy before and after the Pringle maneuver and conducted a TMT-based proteomic analysis through quantitative high-throughput mass spectrometry. We used a fold-change threshold of 1.3 and a t-test p-value?

SUBMITTER: Cai H 

PROVIDER: S-EPMC7788958 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Global proteome profiling of human livers upon ischemia/reperfusion treatment.

Cai Haijian H   Qi Shunli S   Yan Qi Q   Ling Jun J   Du Jian J   Chen Lijian L  

Clinical proteomics 20210106 1


Hepatic ischemia/reperfusion (I/R) injury represents a major risk factor for liver transplantation and is related to graft dysfunction and acute/chronic rejection. However, a significant part of these processes remain poorly characterized. To reveal differences in the proteome during liver I/R injury, we collected human liver biopsy samples during hepatectomy before and after the Pringle maneuver and conducted a TMT-based proteomic analysis through quantitative high-throughput mass spectrometry.  ...[more]

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