MGlu3 receptor regulates microglial cell reactivity in neonatal rats.

ABSTRACT:

Background

Perinatal inflammation is a key factor of brain vulnerability in neonates born preterm or with intra-uterine growth restriction (IUGR), two leading conditions associated with brain injury and responsible for neurocognitive and behavioral disorders. Systemic inflammation is recognized to activate microglia, known to be the critical modulators of brain vulnerability. Although some evidence supports a role for metabotropic glutamate receptor 3 (mGlu3 receptor) in modulation of neuroinflammation, its functions are still unknown in the developing microglia.

Methods

We used a double-hit rat model of perinatal brain injury induced by a gestational low-protein diet combined with interleukin-1β injections (LPD/IL-1β), mimicking both IUGR and prematurity-related inflammatio

SUBMITTER: Zinni M 

PROVIDER: S-EPMC7789385 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature