Dataset Information
XPF expression and its relationship with the risk and prognosis of colorectal cancer.
Ontology highlight
ABSTRACT: Background
XPF (xeroderma pigmentosum complementation group F) is a key factor contributing to DNA damage excision of nucleotide excision repair pathway. The relationship between XPF expression and the risk and prognosis of colorectal cancer (CRC) is unclear.Methods
In this experiment, a total of 824 cases of colorectal tissue were collected. XPF protein expression was detected by immunohistochemical staining. We conducted a Mann-Whitney U test in order to explore the differential expression of XPF between CRC and non-cancer controls, and the correlation between XPF expression and CRC clinicopathological parameters. Univariate and multivariate Cox regression analyses were conducted to investigate the relationship between XPF expression and CRC prognosis. The Java based software GSEA as well as STRING, David, GO, KEGG were used to explore the function and regulation network of XPF.Results
The results demonstrated that the XPF expression in CRC was significantly up-regulated compared with non-tumor controls (P?ConclusionsXPF might be a promising biomarker for CRC risk, and also showed potential as a prognostic predictor in CRC patients.
SUBMITTER: Hu H
PROVIDER: S-EPMC7789628 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
XPF expression and its relationship with the risk and prognosis of colorectal cancer.
Cancer cell international 20210106 1
<h4>Background</h4>XPF (xeroderma pigmentosum complementation group F) is a key factor contributing to DNA damage excision of nucleotide excision repair pathway. The relationship between XPF expression and the risk and prognosis of colorectal cancer (CRC) is unclear.<h4>Methods</h4>In this experiment, a total of 824 cases of colorectal tissue were collected. XPF protein expression was detected by immunohistochemical staining. We conducted a Mann-Whitney U test in order to explore the differentia ...[more]