An RNA Repair Operon Regulated by Damaged tRNAs.
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ABSTRACT:
SUBMITTER: Hughes KJ
PROVIDER: S-EPMC7790460 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
An RNA Repair Operon Regulated by Damaged tRNAs.
Hughes Kevin J KJ Chen Xinguo X Burroughs A Maxwell AM Aravind L L Wolin Sandra L SL
Cell reports 20201201 12
Many bacteria contain an RNA repair operon, encoding the RtcB RNA ligase and the RtcA RNA cyclase, that is regulated by the RtcR transcriptional activator. Although RtcR contains a divergent version of the CARF (CRISPR-associated Rossman fold) oligonucleotide-binding regulatory domain, both the specific signal that regulates operon expression and the substrates of the encoded enzymes are unknown. We report that tRNA fragments activate operon expression. Using a genetic screen in Salmonella enter ...[more]
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