Dataset Information

Interleukin-18 and interferon-? single nucleotide polymorphisms in Egyptian patients with tuberculosis.

ABSTRACT:

Background

Interleukin-18 (IL-18) and interferon-? (IFN-?) are cytokines of crucial role in inflammation and immune reactions. There is a growing evidence supporting important roles for IL-18 and IFN ? in tuberculosis (TB) infection and anti-tuberculosis immunity.

Objective

To evaluate the role of polymorphisms in IL-18-607 and -137 and INF-? +874 in susceptibility to TB infection among Egyptian patients.

Methods

A case control study was conducted to investigate the polymorphism at IL-18-607, -137 and INF-?+874 by sequence specific primer-polymerase chain reaction (SSP- PCR) in 105 patients with pulmonary and extra pulmonary tuberculosis and 106 controls.

Results

A significant protective effect against TB was found in homozygous CC genotype at IL-18 -137G/C, in addition to a 7-fold risk with GG and GC genotypes in the recessive model. Apart from a decreased risk with the AC genotype, no association was detected between the susceptibility to TB and different genotypes or alleles at the IL-18 -607A/C site. The homozygous AA genotype in INF-?+874 showed a significant higher risk to TB than the homozygous TT or heterozygous AT genotypes with nearly a 2-fold risk of TB infection with the A allele. Regarding haplotype association, the GC haplotype was strongly associated with TB infection compared to other haplotypes.

Conclusion

These findings suggest; for the first time in Egypt; a significant risk to TB infection with SNP at the IL-18-137G/C with no LD with SNP at the IL-18-607 site. The homozygous AA genotype in INF-?+874 showed a significant higher risk to TB than the homozygous TT or heterozygous AT genotypes.

SUBMITTER: Hassuna NA

PROVIDER: S-EPMC7790531 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis.

Hassuna Noha A NA El Feky Mohamed M Hussein Aliae A R Mohamed AARM Mahmoud Manal A MA Idriss Naglaa K NK Abdelwahab Sayed F SF Ibrahim Maggie A MA

PloS one 20210107 1

<h4>Background</h4>Interleukin-18 (IL-18) and interferon-γ (IFN-γ) are cytokines of crucial role in inflammation and immune reactions. There is a growing evidence supporting important roles for IL-18 and IFN γ in tuberculosis (TB) infection and anti-tuberculosis immunity.<h4>Objective</h4>To evaluate the role of polymorphisms in IL-18-607 and -137 and INF-γ +874 in susceptibility to TB infection among Egyptian patients.<h4>Methods</h4>A case control study was conducted to investigate the polymor ...[more]

PMID: 33412574

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