Ontology highlight
ABSTRACT:
SUBMITTER: Drumm BT
PROVIDER: S-EPMC7790594 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Drumm Bernard T BT Rembetski Benjamin E BE Huynh Kaitlin K Nizar Aqeel A Baker Salah A SA Sanders Kenton M KM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20200615 8
Colonic intramuscular interstitial cells of Cajal (ICC-IM) are associated with cholinergic varicosities, suggesting a role in mediating excitatory neurotransmission. Ca<sup>2+</sup> release in ICC-IM activates Ano1, a Ca<sup>2+</sup> -activated Cl<sup>-</sup> conductance, causing tissue depolarization and increased smooth muscle excitability. We employed Ca<sup>2+</sup> imaging of colonic ICC-IM in situ, using mice expressing GCaMP6f in ICC to evaluate ICC-IM responses to excitatory neurotransmi ...[more]