Dataset Information
SICI during changing brain states: Differences in methodology can lead to different conclusions.
Ontology highlight
ABSTRACT: Background
Short-latency intracortical inhibition (SICI) is extensively used to probe GABAergic inhibitory mechanisms in M1. Task-related changes in SICI are presumed to reflect changes in the central excitability of GABAergic pathways. Usually, the level of SICI is evaluated using a single intensity of conditioning stimulus so that inhibition can be compared in different brain states.Objective
Here, we show that this approach may sometimes be inadequate since distinct conclusions can be drawn if a different CS intensity is used.Methods
We measured SICI using a range of CS intensities at rest and during a warned simple reaction time task.Conclusions
Our results show that SICI changes that occurred during the task could be either larger or smaller than at rest depending on the intensity of the CS. These findings indicate that careful interpretation of results are needed when a single intensity of CS is used to measure task-related physiological changes.
SUBMITTER: Ibanez J
PROVIDER: S-EPMC7790761 | biostudies-literature | 2020 Mar - Apr
REPOSITORIES: biostudies-literature
Publications
SICI during changing brain states: Differences in methodology can lead to different conclusions.
Brain stimulation 20191104 2
<h4>Background</h4>Short-latency intracortical inhibition (SICI) is extensively used to probe GABAergic inhibitory mechanisms in M1. Task-related changes in SICI are presumed to reflect changes in the central excitability of GABAergic pathways. Usually, the level of SICI is evaluated using a single intensity of conditioning stimulus so that inhibition can be compared in different brain states.<h4>Objective</h4>Here, we show that this approach may sometimes be inadequate since distinct conclusion ...[more]
